Effects of Ketamine On Precipitated Opioid Withdrawal Under General Anaesthesia

Ketamine

Brief Summary

The purpose of this study is to determine whether low-dose ketamine infusion is effective in suppressing the symptoms of opiate withdrawal during rapid opiate antagonist induction (RAI).

Intervention / Treatment

  • Ketamine (DRUG)
    N/A

Condition or Disease

  • Opiate Dependence

Phase

  • Phase 4

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years to 35 Years
    Enrollment: 60 ()
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Treatment

    Masking

    Clinical Trial Dates

    Start date: Feb 01, 2003
    Primary Completion: Aug 31, 2020
    Completion Date: Jun 01, 2006
    Study First Posted: Mar 09, 2006 ESTIMATED
    Results First Posted: Aug 31, 2020
    Last Updated: Nov 13, 2006

    Sponsors / Collaborators

    Lead Sponsor: Vilnius University
    Responsible Party: N/A
    No responsible party listed

    Location

    Vilnius, Lithuania

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 35
    Age Groups: Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * Diagnosed opiate dependence according to ICD 10 and/or DSM 4;
    * Duration of substance abuse more than 1 year
    * No or minor co-morbidities;
    * Grade I-II according to physical status classification system of American Society of Anesthesiologists.

    Exclusion Criteria:

    * Current history of long acting opiate or poly-substance abuse;
    * Acute medical or surgical condition;
    * Pregnancy;
    * Breastfeeding.

    More Details

    NCT Number: NCT00300794
    Other IDs: PROT N1 V1_5
    Study URL: https://clinicaltrials.gov/study/NCT00300794
    Last updated: Sep 29, 2023