Reversal of Ketamine Pharmacodynamic Effects With Naloxone

Brief Summary

The purpose of this study is to determine whether the analgetic and other effects effect of ketamine are partly mediated through opioid receptors

Intervention / Treatment

  • Drug: Saline
  • Drug: Saline + Ketamine
  • Drug: Naloxone + Placebo
  • Drug: Naloxone + Ketamine

Condition or Disease

  • Pain

Phase

Study Design

Study type: Interventional
Status: Terminated
Study results: No Results Available
Age: 18 Years to 30 Years   (Adult)
Enrollment: 3 ()
Funded by: Other

Masking

Clinical Trial Dates

Start date: Dec 09, 2020
Primary Completion: Dec 17, 2020
Completion Date: Dec 17, 2020
Study First Posted: Jun 16, 2009
Results First Posted: Aug 31, 2020
Last Updated: Apr 05, 2018

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Location

Ketamine er et dissociative anaesthetic closely related with phencyclidine (PCP). Phencyclidine is a non-competitive NMDA-antagonist, and it is assumed that the pharmacodynamic mechanism of action for ketamine is the same. Receptor binding studies shows that ketamine has affinity to many receptor types, including opioid mu and kappa receptors. Ketamine has only about 25 times lower affinity for kappa receptors than for the NMDA-receptor complex. Naloxone is a specific antagonist for opioid receptors and block both mu og kappa receptors. A dose of naloxone 10 times larger than required to block mu receptors is required to block kappa receptors. Experiments with naloxone suggest that ketamine is not a mu agonist, but experiments with sufficient large naloxone doses to block kappa receptors have not been carried out in humans.

Eligibility Criteria

Sex: Female
Minimum Age: 18
Maximum Age: 30

More Details

NCT Number: NCT00921765
Other IDs: DOK-018
Study URL: https://ClinicalTrials.gov/show/NCT00921765
Last updated: Mar 18, 2021