Reversal of Ketamine Pharmacodynamic Effects With Naloxone
Brief Summary
The purpose of this study is to determine whether the analgetic and other effects effect of ketamine are partly mediated through opioid receptors
Intervention / Treatment
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Drug: Saline
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Drug: Saline + Ketamine
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Drug: Naloxone + Placebo
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Drug: Naloxone + Ketamine
Condition or Disease
- Pain
Phase
Study Design
Study type: | Interventional |
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Status: | Terminated |
Study results: | No Results Available |
Age: | 18 Years to 30 Years (Adult) |
Enrollment: | 3 () |
Funded by: | Other |
Masking |
Clinical Trial Dates
Start date: | Dec 09, 2020 | |
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Primary Completion: | Dec 17, 2020 | |
Completion Date: | Dec 17, 2020 | |
Study First Posted: | Jun 16, 2009 | |
Results First Posted: | Aug 31, 2020 | |
Last Updated: | Apr 05, 2018 |
Sponsors / Collaborators
Lead Sponsor:
N/A
Responsible Party:
N/A
Location
Ketamine er et dissociative anaesthetic closely related with phencyclidine (PCP). Phencyclidine is a non-competitive NMDA-antagonist, and it is assumed that the pharmacodynamic mechanism of action for ketamine is the same. Receptor binding studies shows that ketamine has affinity to many receptor types, including opioid mu and kappa receptors. Ketamine has only about 25 times lower affinity for kappa receptors than for the NMDA-receptor complex. Naloxone is a specific antagonist for opioid receptors and block both mu og kappa receptors. A dose of naloxone 10 times larger than required to block mu receptors is required to block kappa receptors. Experiments with naloxone suggest that ketamine is not a mu agonist, but experiments with sufficient large naloxone doses to block kappa receptors have not been carried out in humans.
Eligibility Criteria
Sex: | Female |
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Minimum Age: | 18 |
Maximum Age: | 30 |
More Details
NCT Number: | NCT00921765 |
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Other IDs: | DOK-018 |
Study URL: | https://ClinicalTrials.gov/show/NCT00921765 |
Last updated: Mar 18, 2021