Memantine Augmentation in Treatment-Resistant Adults With Obsessive-Compulsive Disorder

Brief Summary

Obsessive-compulsive disorder (OCD) is a common psychiatric illness that affects up to 2-3% of the population. People with OCD experience anxiety-provoking, intrusive thoughts, known as obsessions, and feel compelled to perform repetitive behaviors, or compulsions. The only medications proven effective for OCD are serotonin reuptake inhibitors (SRIs), but even with SRI treatment, most patients continue to experience significant OCD symptoms, impaired functioning, and diminished quality of life. Recent evidence suggest that a different neurotransmitter, glutamate, may contribute to the symptoms in OCD. Medications that target glutamate hold promise for ameliorating symptoms for those patients continuing to suffer from OCD. In this study the investigators are recruiting patients to receive the drug memantine, which is thought to modulate the neurotransmitter glutamate, added to whatever other OCD medications they are taking.

Open label memantine will be titrated in 5mg increments weekly to target dose of 10mg po bid for up to 6 weeks. Memantine will be continued to 12 weeks in those with treatment response,13 either previous response to ketamine (≥ 35% Y-BOCS reduction 1 week after IV ketamine) or current response to memantine (≥ 35% Y-BOCS reduction from pre- to post-6 weeks of memantine).

Intervention / Treatment

  • Drug: Memantine

Condition or Disease

  • Obsessive-Compulsive Disorder

Phase

Study Design

Study type: Interventional
Status: Completed
Study results: Has Results
Age: 18 Years to 65 Years   (Adult, Older Adult)
Enrollment: 12 ()
Funded by: Other

Masking

Clinical Trial Dates

Start date: Aug 09, 2020
Primary Completion: Dec 15, 2020
Completion Date: Dec 15, 2020
Study First Posted: Aug 11, 2009
Results First Posted: May 10, 2017
Last Updated: Jun 21, 2017

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

see above

Eligibility Criteria

Sex: All
Minimum Age: 18
Maximum Age: 65

More Details

NCT Number: NCT00956085
Other IDs: 6924R/5972
Study URL: https://ClinicalTrials.gov/show/NCT00956085
Last updated: Jan 27, 2021