A less than 9 microgram/dl increase in serum cortisol after stimulation with adrenocorticotropic hormone
A Comparison of Etomidate and Ketamine for Anesthesia Induction in Coronary Artery Bypass Graft Surgery
Brief Summary
The aim of this study is to determine whether ketamine is an acceptable alternative to etomidate for anesthesia induction in coronary artery bypass graft surgery in terms of hemodynamic stability and also to compare these agents regarding their effect on adrenal gland steroid synthesis in these patients.
Intervention / Treatment
-
Ketamine (DRUG)During standard anesthesia induction with fentanyl and midazolam, ketamine 2 mg/kg IV will be administered
-
Etomidate (DRUG)During standard anesthesia induction with fentanyl and midazolam, etomidate 3 mg/kg IV will be administered
Condition or Disease
- Coronary Artery Bypass Surgery
Phase
Study Design
| Study type: | INTERVENTIONAL |
|---|---|
| Status: | Unknown status |
| Study results: | No Results Available |
| Age: | 30 Years to 80 Years |
| Enrollment: | 40 (ESTIMATED) |
| Funded by: | Other |
| Allocation: | Randomized |
| Primary Purpose: | Treatment |
Masking |
|
Clinical Trial Dates
| Start date: | Mar 01, 2011 | |
|---|---|---|
| Primary Completion: | Dec 01, 2011 | ESTIMATED |
| Completion Date: | Mar 01, 2012 | ESTIMATED |
| Study First Posted: | Jul 01, 2011 | ESTIMATED |
| Results First Posted: | Aug 31, 2020 | |
| Last Updated: | Jun 30, 2011 |
Sponsors / Collaborators
Lead Sponsor:
N/A
Responsible Party:
N/A
Location
Eligibility Criteria
| Sex: | All |
|---|---|
| Minimum Age: | 30 |
| Maximum Age: | 80 |
| Healthy Volunteers: | Yes |
Inclusion Criteria:
* Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass
* Patient's written informed consent for study participation
* Ejection fraction ≥ 35%
Exclusion Criteria:
* Allergy to study drugs
* Redo surgery
* Patients scheduled for elective coronary artery bypass graft surgery with cardiopulmonary bypass
* Patient's written informed consent for study participation
* Ejection fraction ≥ 35%
Exclusion Criteria:
* Allergy to study drugs
* Redo surgery
Primary Outcomes
-
A more than 15% change in mean arterial pressure and heart rate after anesthesia induction For 60 minutes after anesthesia induction
Secondary Outcomes
More Details
| NCT Number: | NCT01386229 |
|---|---|
| Other IDs: | KA-10-114 |
| Study URL: | https://clinicaltrials.gov/study/NCT01386229 |
Last updated: Sep 29, 2023