Study of NMDA Antagonists and Neuropathic Pain

Brief Summary

The aim of this study is to evaluate if memantine or dextromethorphan gave in relay to ketamine maintains or induces a decrease of pain intensity.

In clinical, after ketamine cure, clinicians have often difficulties to treat patients in order to maintain analgesia or suggest another treatment if analgesia induced by ketamine was not effective, which occurs in one quarter of patients. It will be very useful for monitoring of painful patients evaluate if memantine or dextromethorphan could be an effective therapeutic alternative in neuropathic pain treatment.

Intervention / Treatment

  • Drug: Dextromethorphan (drug used like antitussive)
  • Drug: Memantine (drug used in Alzheimer's disease)
  • Drug: Placebo (lactose)

Condition or Disease

  • Neuropathic Pain

Phase

Study Design

Study type: Interventional
Status: Completed
Study results: No Results Available
Age: 18 Years and older   (Adult, Older Adult)
Enrollment: 7 ()
Funded by: Other

Masking

Clinical Trial Dates

Start date: May 12, 2020
Primary Completion: Jun 14, 2020
Completion Date: Sep 07, 2016
Study First Posted: May 18, 2012
Results First Posted: Aug 31, 2020
Last Updated: Oct 11, 2017

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

The aim of this study is to evaluate if memantine or dextromethorphan gave in relay to ketamine maintains or induces a decrease of pain intensity.

In clinical, after ketamine cure, clinicians have often difficulties to treat patients in order to maintain analgesia or suggest another treatment if analgesia induced by ketamine was not effective, which occurs in one quarter of patients. It will be very useful for monitoring of painful patients evaluate if memantine or dextromethorphan could be an effective therapeutic alternative in neuropathic pain treatment.

Eligibility Criteria

Sex: All
Minimum Age: 18

More Details

NCT Number: NCT01602185
Acronym: NMDA
Other IDs: CHU-0112
Study URL: https://ClinicalTrials.gov/show/NCT01602185
Last updated: Jan 28, 2021