A Comparison of the Effects of Ketamine and Remifentanil on Serum Cystatin-c Levels in CABG Surgery

Ketamine

Brief Summary

In this prospective, randomized, clinical trial, we have investigated the effects of ketamine-based and remifentanil-based anesthetic protocol on perioperative serum cystatin-c levels, and creatinine and/or cystatin-c based eGFR equations in terms of acute kidney injury in CABG surgery.This study was approved by the Ethics Committee of Hospital and all patients were informed and gave written consent. Patients scheduled for elective CABG with cardiopulmonary bypass. Patients were randomly allocated to anesthesia with remifentanil-propofol-midazolam (RPM) group or ketamine-propofol-midazolam (KPM) group. Blood samples were obtained before induction of anesthesia (baseline), at the end of the operation, and postoperative days 1, 2, and 4.

Intervention / Treatment

  • Remifentanil (DRUG)
    renal function
  • Ketamine (DRUG)
    renal function

Condition or Disease

  • Coronary Artery Disease

Phase

  • Phase 4

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years and older   (Adult, Older Adult)
    Enrollment: 37 (ACTUAL)
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Prevention

    Masking

    Clinical Trial Dates

    Start date: May 01, 2013
    Primary Completion: Jul 01, 2013 ACTUAL
    Completion Date: Sep 01, 2013 ACTUAL
    Study First Posted: Apr 14, 2014 ESTIMATED
    Results First Posted: Aug 31, 2020
    Last Updated: Apr 09, 2014

    Sponsors / Collaborators

    Lead Sponsor: Turkiye Yuksek Ihtisas Education and Research Hospital
    Responsible Party: N/A

    Location

    Ankara, Turkey
    Aslı Demir, Ankara, Turkey

    Participant Groups

    • remifentanil, short acting opioid

    • ketamine, intravenous anesthetic

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Age Groups: Adult / Older Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    patients undergoing elective CABG with cardiopulmonary bypass

    Exclusion Criteria:

    patients undergoing emergency operation, combined operation, off-pump surgery, repeat surgery or valve surgery, patients presenting with chronic kidney disease or renal impairment, patients younger than 18 years old and neurological and/or psychiatric disturbances.

    Primary Outcomes
    • creatinin, BUN 2 months
    Secondary Outcomes
    • Cystatin-c level 2 months
    Other Outcomes
    • GFR value 2 months

    More Details

    NCT Number: NCT02113150
    Other IDs: TurkiyeYIH
    Study URL: https://clinicaltrials.gov/study/NCT02113150
    Last updated: Sep 29, 2023