Methadone and Ketamine for Neuropathic Pain Treatment
Brief Summary
Condition or Disease
- Neuropathic Pain
Phase
Study Design
| Study type: | Interventional |
|---|---|
| Status: | Completed |
| Study results: | No Results Available |
| Age: | 22 Years to 77 Years (Adult, Older Adult) |
| Enrollment: | 37 () |
| Funded by: | Other |
Masking |
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Clinical Trial Dates
| Start date: | Jan 12, 2022 | |
|---|---|---|
| Primary Completion: | Aug 12, 2022 | |
| Completion Date: | Aug 12, 2022 | |
| Study First Posted: | Sep 08, 2014 | |
| Results First Posted: | Aug 31, 2020 | |
| Last Updated: | Sep 08, 2014 |
Sponsors / Collaborators
Either oral methadone or ketamine have been used in neuropathic pain management, however, the benefits of the association of both drugs are uncertain. Here, we conducted a randomized, double-blind, in parallel, active controlled clinical trial to test the hypothesis that methadone combined ketamine (methadone/ketamine) is more effective than methadone or ketamine alone in reducing neuropathic pain.
Methods: Fourthly two patients with neuropathic pain refractory to conventional therapy were randomly assigned to receive during three months oral methadone (n= 13), ketamine (n=13) or methadone combined with ketamine (n=13). The primary outcome was pain score on visual analogical scale (VAS) assessed on baseline, 8, 15, 30, 60 and 90 days throughout the treatment, and the secondary outcomes were symptoms of neuropathic pain such as allodynia, burning or shooting pain as well the side effects.
Eligibility Criteria
| Sex: | All |
|---|---|
| Minimum Age: | 22 |
| Maximum Age: | 77 |
More Details
| NCT Number: | NCT02233452 |
|---|---|
| Other IDs: | Methadone plus ketamine |
| Study URL: | https://ClinicalTrials.gov/show/NCT02233452 |