Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine

Ketamine

Brief Summary

Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents. The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.

Intervention / Treatment

  • glycopyrrolate (DRUG)
    Intravenously administered 0.005mg/Kg of glycopyrrolate in intervention group

Condition or Disease

  • Fever

Phase

  • Not Applicable

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 12 Months to 8 Years
    Enrollment: 84 (ACTUAL)
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Prevention

    Masking

    QUADRUPLE:
    • Participant
    • Care Provider
    • Investigator
    • Outcomes Assessor

    Clinical Trial Dates

    Start date: May 01, 2014
    Primary Completion: Nov 01, 2014 ACTUAL
    Completion Date: Dec 01, 2014 ACTUAL
    Study First Posted: Apr 30, 2015 ESTIMATED
    Results First Posted: Aug 31, 2020
    Last Updated: Apr 29, 2015

    Sponsors / Collaborators

    Lead Sponsor: Inje University
    Responsible Party: N/A

    Location

    South Korea
    Gyeong-gi Do, South Korea

    Participant Groups

    • Premedication with 0.005mg/Kg of glycopyrrolate

    • Same volume of normal saline

    Eligibility Criteria

    Sex: All
    Minimum Age: 1
    Maximum Age: 8
    Age Groups: Child
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * American Society of Anesthesiologists (ASA) Physical Status classification I
    * underwent surgery between 8 to 9 am
    * undergoing ambulatory anesthesia with ketamine

    Exclusion Criteria:

    * who required endotracheal intubation
    * who were administered with medications other than ketamine

    Primary Outcomes

    • measured body temperature at three times in both ears and the highest value was selected.

    Secondary Outcomes

    • Oral secretion during the whole procedure was recorded by the researcher

    More Details

    NCT Number: NCT02430272
    Other IDs: DSC-01-choe
    Study URL: https://clinicaltrials.gov/study/NCT02430272
    Last updated: Sep 29, 2023