Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

Brief Summary

Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam, which is non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for postoperative pain control, and reduce the needs of opioid.

Intervention / Treatment

  • Drug: Nefopam
  • Drug: Ketamine
  • Drug: Saline

Condition or Disease

  • Cholecystitis

Phase

Study Design

Study type: Interventional
Status: Unknown status
Study results: No Results Available
Age: 20 Years to 65 Years   (Adult, Older Adult)
Enrollment: 60 ()
Funded by: Other

Masking

Clinical Trial Dates

Start date: Mar 15, 2020
Primary Completion: Dec 15, 2020
Completion Date: Aug 31, 2020
Study First Posted: Jul 09, 2015
Results First Posted: Aug 31, 2020
Last Updated: Sep 02, 2015

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Eligibility Criteria

Sex: All
Minimum Age: 20
Maximum Age: 65

More Details

NCT Number: NCT02493231
Other IDs: 2014-10-133
Study URL: https://ClinicalTrials.gov/show/NCT02493231
Last updated: Jan 27, 2021