Ketamine Combination With Spinal Morphine for Post Thoracic Surgery Pain : A Randomized Control Study

Ketamine

Brief Summary

Thoracotomy is one of the most painful operation. Continuous thoracic epidural or paravertebral analgesia are gold standard for postoperative pain. But both techniques require skills. Spinal morphine is alternative simple method with less efficacy. Adding low dose ketamine during intraoperative may be helpful in postoperative pain relief.

Intervention / Treatment

  • NSS (OTHER)
    NSS infusion
  • Ketamine (DRUG)
    Ketamine 0.2 mg/kg/hr intravenous infusion

Condition or Disease

  • Pain
  • Postoperative Period

Phase

  • Phase 4

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years to 70 Years
    Enrollment: 32 (ACTUAL)
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Treatment

    Masking

    QUADRUPLE:
    • Participant
    • Care Provider
    • Investigator
    • Outcomes Assessor

    Clinical Trial Dates

    Start date: Oct 01, 2017 ACTUAL
    Primary Completion: Dec 31, 2018 ACTUAL
    Completion Date: Dec 31, 2018 ACTUAL
    Study First Posted: Oct 07, 2015 ESTIMATED
    Results First Posted: Aug 31, 2020
    Last Updated: Aug 31, 2021

    Sponsors / Collaborators

    Lead Sponsor: Mahidol University
    Responsible Party: N/A

    Location

    Bangkok, Thailand

    Participant Groups

    • NSS infusion

    • Ketamine 0.2 mg/kg/hr intravenous infusion

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 70
    Age Groups: Adult / Older Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * ASA physical status 1-3
    * elective thoracotomy
    * can operate patient-controlled analgesia (PCA) machine

    Exclusion Criteria:

    patient with history of

    * allergy to morphine or ketamine
    * contraindicate to ketamine
    * remain intubated in the postoperative period

    Primary Outcomes

    • Time to first trigger of morphine

    Secondary Outcomes

    • 24-hr morphine consumption

    • NRS score (0-10) was assessed at at 6, 24 hours postoperative

    • Incidence of nausea and vomiting

    More Details

    NCT Number: NCT02570230
    Other IDs: SI2558
    Study URL: https://clinicaltrials.gov/study/NCT02570230
    Last updated: Sep 29, 2023