Brain Derived Neurotropic Factor Response to Aerobic Exercise Intensity in Depressive Patients.

LSD

Brief Summary

Acute aerobic exercise improves affective stats in patients with mental illnesses. Brain derived neurotropic factor (BDNF) may be a biological mechanism that contributes to the affective benefits. The magnitude of the increase of serum BDNF might be exercise intensity dependent, but no study has compared low high-aerobic-intensity training at 90-95 % of the maximal heart rate (HRmax) with long-slow-distance training at 70 % of the HRmax in patients with depression. The aim of this study is to compare changes in serum BDNF levels after high-aerobic-intensity training and long-slow-distance training in a intra-individual design in patients suffering from depression. The results will give indications of a possible difference in BDNF response between aerobic intensities and may be uses as pilot data for calculating sample size.

Intervention / Treatment

  • High aerobic intensity training (HIT) (BEHAVIORAL)
    One training session, high aerobic intensity training (HIT) at 90-95 % of the maximal heart rate (HRmax)
  • Long slow distance training (LSD) (BEHAVIORAL)
    One training session, long slow distance training (LSD) at 70 % of the HRmax

Condition or Disease

  • Depressive Disorder
  • Depressive Disorder, Major

Phase

  • Not Applicable

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years to 65 Years
    Enrollment: 21 (ACTUAL)
    Allocation: N/A
    Primary Purpose: Treatment

    Masking

    Clinical Trial Dates

    Start date: Mar 01, 2016 ACTUAL
    Primary Completion: Dec 01, 2016 ACTUAL
    Completion Date: Dec 01, 2016 ACTUAL
    Study First Posted: Apr 18, 2016 ESTIMATED
    Last Updated: Dec 03, 2018

    Sponsors / Collaborators

    Lead Sponsor: St. Olavs Hospital
    Lead sponsor is responsible party
    Responsible Party: N/A

    Participant Groups

    • Acute High aerobic intensity training (HIT) and long slow distance training (LSD)

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 65
    Age Groups: Adult / Older Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * Moderate or severe depression (ICD10: F32-F33)

    Exclusion Criteria:

    * Bipolar disorder.

    Primary Outcomes

    • To measure serum BDNF levels, blood samples will be taken before and after each workout session.

    Secondary Outcomes

    • The positive and negative affect schedule (PANAS) .

    • A short form of state trait anxiety inventory for adults (STAI) is used to detect their state of anxiety.

    • The Subjective exercise experience scale (SEES).

    • Maximal oxygen uptake Baseline
    • Maximal Heart rate Baseline

    More Details

    NCT Number: NCT02741622
    Other IDs: 2015/2230
    Study URL: https://clinicaltrials.gov/study/NCT02741622
    Last updated: Sep 29, 2023