Ketamine Versus Dexmedetomidine With Local Anesthetic in TAP Block

Ketamine

Brief Summary

Comparing the analgesic effects of ketamine and dexmedetomidine when added to local anesthetic in TAP block for postoperative analgesia after lower abdominal cancer surgery.

Intervention / Treatment

  • Ketamine (DRUG)
    Ketamine at a dose of 0.5mg/kg will be added to bupivacaine 0.25 (total volume 20ml) in each side using sonar guided TAP block
  • Dexmedetomidine (DRUG)
    dexmedetomidine at a dose of 1ug/kg will be added to bupivacaine 0.25 (total volume 20ml) in each side using sonar guided TAP block
  • Control group (DRUG)
    20ml of 0.25% bupivacaine will be injected in each side of the TAP block

Condition or Disease

  • Postoperative Analgesia
  • Lower Abdominal Cancer

Phase

  • Phase 2
  • Phase 3

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years to 65 Years
    Enrollment: 90 (ACTUAL)
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Treatment

    Masking

    QUADRUPLE:
    • Participant
    • Care Provider
    • Investigator
    • Outcomes Assessor

    Clinical Trial Dates

    Start date: Mar 10, 2017 ACTUAL
    Primary Completion: Jun 25, 2017 ACTUAL
    Completion Date: Jul 01, 2017 ACTUAL
    Study First Posted: Feb 23, 2017 ACTUAL
    Results First Posted: Aug 31, 2020
    Last Updated: Jul 01, 2017

    Sponsors / Collaborators

    Lead Sponsor: Assiut University
    Responsible Party: N/A

    Participant Groups

    • saline in the same volume will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery

    • ketamine in a dose of 0.5mg/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery

    • dexmedetomidine in a dose of 1ug/kg will be added to the local anesthetic for TAP block in patients undergoing abdominal cancer surgery

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 65
    Age Groups: Adult / Older Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * All patients ASA I and II to whom abdominal surgery for cancer will be conducted will be included in the study

    Exclusion Criteria:

    * Coagulopathies
    * ASA III or IV, patient refusal, sensitivity to the used drugs

    Primary Outcomes

    • postoperative rescue morphine consumption

    More Details

    NCT Number: NCT03060070
    Other IDs: 321
    Study URL: https://clinicaltrials.gov/study/NCT03060070
    Last updated: Sep 29, 2023