The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection

Brief Summary

Systemic inflammation caused by surgery may aggravate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. ketamine, a N-methyl-D-asparate receptor antangonist, has anti-inflammatory activity and opioid-sparing effect. This study investigate the effect of intraopertaive ketamine administration on immune function in patients undergoing laparoscopic colorectal cancer resection.

Intervention / Treatment

  • Drug: Ketamine
  • Drug: Saline

Condition or Disease

  • Colorectal Cancer

Phase

Study Design

Study type: Interventional
Status: Recruiting
Study results: No Results Available
Age: 20 Years to 80 Years   (Adult, Older Adult)
Enrollment: 100 ()
Funded by: Other

Masking

Clinical Trial Dates

Start date: Sep 01, 2017
Primary Completion: Jul 20, 2020
Completion Date: Jul 20, 2020
Study First Posted: Sep 06, 2017
Results First Posted: Aug 31, 2020
Last Updated: Jan 16, 2019

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Eligibility Criteria

Sex: All
Minimum Age: 20
Maximum Age: 80

This clinical trial is recruiting

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More Details

NCT Number: NCT03273231
Other IDs: 4-2017-0475
Study URL: https://ClinicalTrials.gov/show/NCT03273231
Last updated: Jun 17, 2022