Co-induction Ketamine-propofol: Effects on Laryngeal Mask Airway Insertion Conditions in Children

Ketamine

Brief Summary

Background: Large doses of propofol needed for induction and laryngeal mask (LM) insertion in children may be associated with hemodynamic sides effects. Co-induction with low doses of ketamine 0.5 mg/ kg has the advantage of reducing dose and therefore maintaining hemodynamic stability.

Aim: To examine the effect of co-induction on LM insertion, hemodynamics and recovery in children

Intervention / Treatment

Drug: Ketamine

Condition or Disease

Anesthesia Intubation Complication

Phase

Study Design

Study type:	Interventional
Status:	Completed
Study results:	No Results Available
Age:	1 Year to 8 Years (Child)
Enrollment:	120 ()
Funded by:	Other
Masking

Clinical Trial Dates

Start date:	May 01, 2019
Primary Completion:	Nov 30, 2019
Completion Date:	Nov 30, 2019
Study First Posted:	Aug 15, 2018
Results First Posted:	Aug 31, 2020
Last Updated:	Apr 16, 2020

Sponsors / Collaborators

Lead Sponsor: N/A

Responsible Party: N/A

Location

Mahdia, Tunisia

A prospective, randomized, double-blind, controlled study was conducted including120 ASA physical status I â II unpremedicated children, aged 1-8 years. Inhalatory induction with sevoflurane at 7% to insert an intravenous canula was first used then decreased to 2%. Normal saline or ketamine (0.5 mg/kg) were administered in groups P (propofol), PK (propofol-ketamine) respectively, 1 min prior to the administration of the induction dose of propofol. Propofol 3mg/kg was used for induction in the 2 groups, LM inserted 60 s later and insertion conditions assessed. Heart rate and blood pressure were recorded immediately after propofol bolus, then after LM insertion, at the 3rd ,5th and 10th minutes later. Recovery was assessed using Steward's Score

Eligibility Criteria

Sex:	All
Minimum Age:	1
Maximum Age:	8

More Details

NCT Number:	NCT03631875
Other IDs:	Ketco1
Study URL:	https://ClinicalTrials.gov/show/NCT03631875

Last updated: Jun 17, 2022