Impact of the Use of Ketamine in Laparoscopic Surgery.

Brief Summary

In order to improve the postoperative period (namely pain control), several drugs can be used. For instance, ketamine is a general anesthetic that holds strong analgesic properties, yet also owns undesirable effects, in which hallucination phenomena is one the most common indicator. However, slight information is available about the real implication in the quality of the recovery on the use of ketamine for postoperative pain treatment. The quality of the recovery includes several health conditions, such as pain, physical comfort, physical independence, psychological support and emotional state. In recent years, investigations in this field has been attracted the attention by the health professionals, since is an indicator of the quality of post-operative care. To evaluate these parameters, questionnaires have been developed, in which the Portuguese version of Quality of Recovery 15 (QoR-15) is include. This questionnaire evaluates five psychometric dimensions. Therefore, the present study has the main goal, the evaluation of the effect of using ketamine in laparoscopic surgery and the quality of the recovery using the QoR-15 questionnaire.

Intervention / Treatment

  • Ketamine (DRUG)
    Administration of 0.5mg / kg ideal body weight of ketamine at induction of anesthesia in laparoscopic surgery.

Condition or Disease

  • Quality of Recovery

Phase

  • Phase 4
  • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years to 65 Years
    Enrollment: 127 (ACTUAL)
    Funded by: Other
    Allocation: Non-Randomized
    Primary Purpose: Screening

    Masking

    Clinical Trial Dates

    Start date: Oct 01, 2018 ACTUAL
    Primary Completion: Oct 01, 2022 ACTUAL
    Completion Date: Apr 01, 2023 ACTUAL
    Study First Posted: Oct 30, 2018 ACTUAL
    Results First Posted: Aug 31, 2020
    Last Updated: May 09, 2023

    Sponsors / Collaborators

    Lead Sponsor: Universidade do Porto
    Lead sponsor is responsible party
    Responsible Party: N/A

    Location

    Participant Groups

    • 20 milliliter of ketamine (0.5mg / kg ideal body weight) at induction of anesthesia.

    • No description provided

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 65
    Age Groups: Adult / Older Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * Patients between 18 and 65 years age, with an American Society of Anesthesiology physical status I, II or III.
    * Laparoscopic surgery (sleeve gastrectomy, salpingectomy, or cholecystectomy)

    Exclusion Criteria:

    * patient refusal, the incapacity of providing informed consent, drug abusers (current or past history) or alcohol abuse, medication with benzodiazepines, inability to give informed consent, pregnant, emergency surgery, psychiatric pathology, existence of surgical complications in the recovery and admission to a level II or III unit ( for any reason).

    Primary Outcomes
    • Difference (improvement or worsening) in the postoperative baseline score (preoperative) in the Portuguese version of the Quality of Recovery questionnaire 15.

    More Details

    NCT Number: NCT03724019
    Other IDs: QuetaminaQOR15
    Study URL: https://clinicaltrials.gov/study/NCT03724019
    Last updated: Sep 29, 2023