Is it Possible to Replace Fentanyl in Anesthesia for Minor Procedures?

Ketamine

Brief Summary

To compare between fentanyl group and ketamine lidocaine group for induction of anesthesia as regards hemodynamics and smooth intubation.

Intervention / Treatment

  • Ketamine (DRUG)
    ketamine
  • Propofol (DRUG)
    propofol
  • Fentanyl (DRUG)
    fentanyl
  • Cisatracurium (DRUG)
    cisatracurium
  • Lidocaine (DRUG)
    lidocaine

Condition or Disease

  • Anesthesia

Phase

  • Not Applicable

    • Study Design

    Study type: INTERVENTIONAL
    Status: Completed
    Study results: No Results Available
    Age: 18 Years to 55 Years
    Enrollment: 120 (ACTUAL)
    Funded by: Other
    Allocation: Randomized
    Primary Purpose: Prevention

    Masking

    DOUBLE:
    • Participant
    • Care Provider

    Clinical Trial Dates

    Start date: Jan 02, 2018 ACTUAL
    Primary Completion: Dec 01, 2018 ACTUAL
    Completion Date: Dec 10, 2018 ACTUAL
    Study First Posted: Jan 16, 2019 ACTUAL
    Results First Posted: Aug 31, 2020
    Last Updated: Jan 15, 2019

    Sponsors / Collaborators

    Lead Sponsor: Ain Shams University
    Responsible Party: N/A

    Location

    Cairo, Egypt

    Two groups each with 60 patients Group I anesthesia initiated by propofol, fentanyl and cisatracurium. Group II anesthesia initiated by ketamine, lidocaine, propofol and cisatracurium.

    Participant Groups

    • Administered propofol and fentanyl for induction.

    • Administered propofol, ketamine and lidocaine for induction.

    Eligibility Criteria

    Sex: All
    Minimum Age: 18
    Maximum Age: 55
    Age Groups: Adult
    Healthy Volunteers: Yes

    Inclusion Criteria:

    * ASA I and II between
    * Age between 18-55 years
    * Undergoing minor surgical procedure less than an hour.

    Exclusion Criteria:

    * Patients with hypertension
    * Patients with Ischemic heart diseases
    * Patients with chronic renal or liver diseases

    Primary Outcomes

    • changes in blood pressure with intubation

    • changes in blood pressure during anesthesia

    • amount of pain killers used and timing

    • changes in pulse rate during anesthesia

    More Details

    NCT Number: NCT03806374
    Other IDs: ASUH9418
    Study URL: https://clinicaltrials.gov/study/NCT03806374
    Last updated: Sep 29, 2023