Stanford Regulating Circuits of the Brain Study - MDMA
Brief Summary
Study Design
| Study type: | Observational |
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| Status: | Recruiting |
| Study results: | No Results Available |
| Age: | 18 Years to 55 Years (Adult) |
| Enrollment: | 40 () |
| Funded by: | Other|NIH |
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Clinical Trial Dates
| Start date: | Nov 02, 2021 | |
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| Primary Completion: | Nov 01, 2024 | |
| Completion Date: | Nov 01, 2025 | |
| Study First Posted: | Aug 16, 2019 | |
| Results First Posted: | Aug 30, 2020 | |
| Last Updated: | Apr 14, 2022 |
Sponsors / Collaborators
Location
The investigators will assess the effect of acute MDMA modulation on the functioning of reward-related human brain circuits. Reward-related brain circuits will be assessed using functional magnetic resonance imaging.
Participants will include volunteers who report more than two prior uses of MDMA (also known as Ecstasy), when they were 18 years or older.
The investigators will recruit individuals who have previously tried MDMA rather than those who are MDMA-naïve.
Participants will receive an oral dose of MDMA (80mg and 120mg) and placebo (saline) at 3 separate study sessions. Following established procedures, these three sessions will be randomized in a blinded protocol in order to limit expectancy effects.
Throughout each session, participants will be monitored. Functional imaging will commence after the drug has reached peak levels, following previously established time courses for MDMA administered orally. Participants will also be monitored after the functional imaging session. Secondary effects of MDMA on behavior and self-reported experience will be assessed.
In the assessment of the acute effects of MDMA, the investigators will take into account the cumulative effects of prior drug exposure.
Eligibility Criteria
| Sex: | All |
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| Minimum Age: | 18 |
| Maximum Age: | 55 |
This clinical trial is recruiting
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More Details
| NCT Number: | NCT04060108 |
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| Acronym: | RBRAIN-MDMA |
| Other IDs: | 52244|1P50DA042012-01A1 |
| Study URL: | https://ClinicalTrials.gov/show/NCT04060108 |