It includes intra- and post-operative adverse cardiac events.
Cardiovascular Protection Conservative Effects of Esketamine Versus µ-opioid Receptor Agonists in General Anesthesia
Esketamine, Sulfentanil or/and Remifentanil (DRUG)The esketamine or the opioids will be intravenously injected or infused to the patients with propofol and one of the muscle relaxants to induce and maitain general anesthesia.
Condition or Disease
- Opioid Analgesic Adverse Reaction
|Study results:||No Results Available|
|Age:||Child, Adult, Older Adult|
Clinical Trial Dates
|Start date:||Nov 02, 2020||ACTUAL|
|Primary Completion:||Jun 30, 2023||ACTUAL|
|Completion Date:||Dec 31, 2023||ESTIMATED|
|Study First Posted:||Sep 17, 2020||ACTUAL|
|Last Updated:||Aug 23, 2023|
Sponsors / Collaborators
This parallel, randomized controlled trial will be conducted in eleven centers in Shanxi province, China, which is designed to investigate the perioperative incidence of adverse cardiovascular events and alteration of cardiac troponin I (cTnI) in the patients (one thousand patients, ASA Physical Status 1-II, older than 16 years, regardless of the gender) undergoing surgery under total intravenous general anesthesia with conventional µ-opioid agonists or Esketamine, as the major analgesic. Clinically appropriate anesthesia depth or BIS readings will be used for judgement of anesthetic depth. Conventional monitoring parameters, including blood pressures, heart rate, SpO2 and ECG, will be recorded and analyzed. Blood samples will be collected at 30 min before induction of anesthesia, at the end of surgery and 24 h after the surgery. The association of the perioperative adverse cardiovascular events and the alterations of the levels of serum TRPV1, CGRP, SP and cTnI in the patients underwent general anesthesia using different analgesics (µ-opioid agonists vs Esketamine) will be evaluated. Postoperative outcome, including the functions of the brain and cardiovascular system, is also going to be traced for 1 year postoperatively.
Mu-opioid receptor agonists (remifentanil, sulfentanil) will be used as the only analgesic(s) in the surgery.
Esketamine will be used as the only anagesic in the surgey.
|Age Groups:||Child / Adult / Older Adult|
* Patients undergoing general anesthesia
* Patients with diabetes and neuropathy
This clinical trial is recruiting
Are you interested in participating in this trial or others? We'd love to help.
The molecules exist in myocardium participating in carioprotection.