Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain

Brief Summary

The long-term objective of this project is to characterize how psilocybin affects visual perception and the brain's representation of the visual environment. We know that psilocybin alters aspects of visual perception, but the underlying brain mechanisms contributing to these effects are poorly understood. The proposed work will address these questions in a large, diverse sample of healthy human subjects by using functional magnetic resonance imaging (fMRI) to measure the brain's responses to visual stimuli. The proposed research will document which brain areas mediate the effects of psilocybin. The technique of fMRI will be employed to measure brain activity in different brain areas while subjects are performing a visual perceptual task.

Intervention / Treatment

  • Drug: Psilocybin

Condition or Disease

  • Perception Disorders

Phase

Study Design

Study type: Interventional
Status: Not yet recruiting
Study results: No Results Available
Age: 21 Years and older   (Adult, Older Adult)
Enrollment: 80 ()
Funded by: Other

Masking

Clinical Trial Dates

Start date: May 01, 2022
Primary Completion: Dec 31, 2025
Completion Date: Dec 31, 2025
Study First Posted: Mar 03, 2022
Last Updated: Mar 03, 2022

Sponsors / Collaborators

Lead Sponsor: N/A
Responsible Party: N/A

Eligibility Criteria

Sex: All

More Details

NCT Number: NCT05265546
Other IDs: 2021-11-14799
Study URL: https://ClinicalTrials.gov/show/NCT05265546
Last updated: Jun 17, 2022