Biotransformation of tryptamine and secologanin into plant terpenoid indole alkaloids by transgenic yeast

Abstract

A transgenic Saccharomyces cerevisiae was constructed containing the cDNAs coding for strictosidine synthase (STR) and strictosidine β-glucosidase (SGD) from the medicinal plant Catharanthus roseus. Both enzymes are involved in the biosynthesis of terpenoid indole …