Cannabinoids prevent the acute hyperthermia and partially protect against the 5-HT depleting effects of MDMA (“Ecstasy”) in rats

Abstract

Cannabinoid–MDMA interactions were examined in male Wistar rats. MDMA (4× 5 mg/kg or 2× 10 mg/kg over 4 h on each of 2 days) was administered with or without Δ 9-tetrahydrocannabinol (THC)(4× 2.5 mg/kg), the synthetic cannabinoid receptor agonist CP …