Comparison of antidepressant and side effects in mice after intranasal administration of (R, S)-ketamine,(R)-ketamine, and (S)-ketamine

Abstract

The N-methyl-d-aspartate receptor (NMDAR) antagonist (R, S)-ketamine produces rapid and sustained antidepressant effects in treatment-resistant patients with depression although intranasal use of (R, S)-ketamine in ketamine abusers is popular. In March 5, 2019, nasal …