Conjugate-base-stabilized brønsted acids: Catalytic enantioselective Pictet–Spengler reactions with unmodified Tryptamine

Abstract

A conjugate-base-stabilized Brønsted acid facilitates catalytic enantioselective Pictet–Spengler reactions with unmodified tryptamine. The chiral carboxylic acid catalyst is readily assembled in just two steps and enables the formation of β-carbolines with up to 92% ee …