Cyclization of Tryptophan and Tryptamine Derivatives to 2,3-Dihydropyrroloindoles

Abstract

N-Acetylated derivatives of tryptophan and tryptamine (1-4) in phosphate buffer at pH 9 with N-bromo-succinimide (NBS) or in methylene chloride containing triethylaminewith f-butyl hypochlorite give acid-labile tricyclic dihydropyrrolo [2, 3-¿>] indoles (5-8) characterized by …