High-affinity binding of 5-hydroxytryptamine to brain synaptosomal membranes: comparison with lysergic acid diethylamide binding

Abstract

[3 H] 5-Hydroxytryptamine ([3 H] 5-HT) binds to crude brain membrane preparations at two different sites (K d= 1-3 nM and 10-30 nM). These two sites are present in a limited number as saturable populations and selectively bind 5-HT and related structures. In the same crude …