Increased anxiety 3 months after brief exposure to MDMA ('Ecstasy') in rats: association with altered 5-HT transporter and receptor density

Abstract

Male Wistar rats were treated with 3, 4-methylenedioxymethamphetamine (MDMA,'Ecstasy') using either a high dose (4× 5 mg/kg over 4 h) or low dose (1× 5 mg/kg over 4 h) regimen on each of 2 consecutive days. After 10 weeks, rats were tested in the social interaction and …