Increased anxiety and" depressive" symptoms months after MDMA (" ecstasy") in rats: drug-induced hyperthermia does not predict long-term outcomes

Abstract

Rationale There is some uncertainty whether the acute hyperthermia caused by MDMA (ecstasy) plays a significant role in determining the long-term neurotoxic effects on brain 5-HT systems and associated changes in mood and behaviour. Objective The present study …