Pharmacology of the Malpighian tubules of Rhodnius and Carausius: the structure-activity relationship of tryptamine analogues and the role of cyclic AMP

Abstract

1. 5-Hydroxytryptamine (5-HT) and a few of its derivatives will cause an acceleration of secretion by the isolated Malpighian tubules of Rhodnius prolixus and Carausius morosus. Substitution in the terminal amino group of 5-HT causes little loss of effect, but changes in …