Signaling pathways underlying the rapid antidepressant actions of ketamine

RS Duman, N Li, RJ Liu, V Duric, G Aghajanian - Neuropharmacology, 2012 - Elsevier

Abstract

Currently available medications have significant limitations, most notably low response rate and time lag for treatment response. Recent clinical studies have demonstrated that ketamine, an NMDA receptor antagonist produces a rapid antidepressant response (within …

Last updated: Jul 27, 2020