Structure activity relations for the inhibition of 5‐HT uptake into rat hypothalamic homogenates by serotonin and tryptamine analogues

Abstract

Various 5‐HT and tryptamine analogues have been examined as inhibitors of [3H] 5‐HT uptake into rat hypothalamic homogenates. Acetylation of the terminal amino group or methylation of the hydroxyl group of 5‐HT resulted in compounds having a reduced affinity …