Structure–activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states

Abstract

The interaction of ibogaine analogs with nicotinic acetylcholine receptors (AChRs) in different conformational states was studied by functional and structural approaches. The results established that ibogaine analogs:(a) inhibit (±)-epibatidine-induced Ca 2+ influx in …