The interaction of ketamine with the opiate receptor

DJ Smith, GM Pekoe, LL Martin, B Coalgate - Life Sciences, 1980 - Elsevier

Abstract

The analgesic effect of the anesthetic agent ketamine HCl is inhibited in rats by the narcotic receptor antagonist naloxone. Racemic (±) ketamine HCl also displaced 3 H-naloxone in an opiate receptor binding-assay. The potency of ketamine in the assay was reduced nearly six …

Last updated: Jul 27, 2020