Total synthesis of (±)-Trigonoliimine C via oxidative rearrangement of an unsymmetrical bis-tryptamine

Abstract

We report the first total synthesis of (±)-trigonoliimine C, a member of a family of structurally complex alkaloids, in 10 steps from tryptamine and 6-methoxytryptamine. Our convergent synthetic strategy relies on a selective oxidative rearrangement of an unsymmetrical 2, 2 …