Tryptoline formation by a preparation from brain with 5-methyltetrahydrofolic acid and tryptamine

Abstract

An enzymatic preparation from human brain converts tryptamine to tryptoline (9H-1, 2, 3, 4-tetrahydropyrido [3, 4-b] indole) in the presence of 5-methyltetrahydrofolic acid. Similarly, N-methyltryptamine and 5-hydroxytryptamine yield 1-methyltryptoline and 5-hydroxytryptoline …